Two offers can both say “98% fisetin” and still be different lots. Common names such as smoke tree or wax tree are not a purchase specification. Compare the stated fisetin percentage together with assay basis, plant part, carrier, and analytical method.

Reference figures apply only where that compendium fits the material and the market. Custom is the approved specification when the buyer’s file differs. They are not a finished-product release specification.

A COA may report fisetin with two calculation methods, such as an external-standard assay and an area-normalization result. Those values stay in separate fields. Other assay levels come from the COA. A trademark is printed only with authorization, and it is not an assay.

For a 100 mg fisetin label claim, a 50% material requires about 200 mg of raw material, while a 98% material requires about 102 mg, before overage and process loss. The resulting fill weight still depends on carrier composition and bulk density.

Compare Two Fisetin COAs

Wholesale fisetin sold by the kilogram in drums. The material line is the same botanical identity, plant part, and assay used for capsules. The price is the drum price.

Minimum: Planning starts at 20–300 kg, depending on the assay and the drum size.

Delivery: The ship date is the date on the order acknowledgement. It is set after botanical identity, plant part, assay, and drum size are approved.

With a finished bottle: Drums and a private-label bottle are two lines on one project. The bottle quantity and schedule are under MOQ and Lead Time.

The finished-product specification is the standard the batch must meet. Finished-product testing is what is run on that batch. Batch release is the decision from those results and the batch records. The COA is the batch file that reports them. Incoming lots stay on the raw-material file.

1. Identity and Appearance
Finished unit, dosage form, appearance, color, and odor. Lot number, expiry or best-before, label and artwork, net contents, and seal or container closure.

2. Potency and Product Specifications
HPLC fisetin in one capsule, tablet, stick, or gummy, on the same assay basis as the raw-material file, against the label claim for that unit. Fill weight, and the unit-to-unit range when the specification sets it. Each companion with a quantitative claim. The carrier, when the specification gives it a quantitative claim.

On that same specification: capsules — average weight, weight variation, and disintegration when required. Tablets — weight variation, hardness, friability, and disintegration. Powder sticks — fill weight, content uniformity, and moisture. Gummies — piece weight, texture, and moisture. A drink or liquid, once its dispersion system is approved, adds appearance and pH.

Sustained release is dissolution at the time points on the specification, when the formula is sustained-release. Stability is the fisetin assay at the condition, duration, and pack on the protocol. A sustained-release formula includes dissolution at those same points.

3. Microbiology and Contaminants
Finished-unit microbiology covers total aerobic count, yeast and mold, E. coli, and Salmonella, plus any other organism the destination specification names, such as coliforms or Staphylococcus aureus.

Heavy metals — lead, arsenic, cadmium, and mercury — use the method named on the specification, commonly ICP-MS or ICP-OES. Pesticide residues, residual solvents, and any further contaminant are named on the finished specification from raw-material risk, dosage form, and the destination market.

4. Documentation and Release Records
Batch test records, the method and specification used, deviation handling, and the release record. The COA is issued from that file. See How to Read a COA and Quality Control.

Study: A 2022 randomized, double-blind, crossover pharmacokinetic study in 15 healthy adults (Journal of Nutritional Science, 2022;11:e74).

Formulation: Micellar fisetin in a fenugreek galactomannan hydrogel, with sunflower lecithin and sunflower oil.

Dose: A single 1,000 mg dose of that formulation delivered 192 mg fisetin. It was compared with 1,000 mg of unformulated fisetin.

Reported Difference: About 26.9-fold for AUC over 12 hours, and about 23.9-fold for Cmax.

Scope: Those results belong to that formulation. They do not transfer to other fisetin–galactomannan blends, to a phospholipid powder, or to an unformulated capsule.

Label claims: The wording printed on the finished label. The brand owner writes it and confirms it for the destination market. A market position is named here when a public file describes the effect that wording points to.

Antioxidant: The single-active shelf. Fisetin is manufactured for antioxidant lines. The brand keeps the substantiation for the sentence it prints.

Healthy aging: A brand shelf position. This manufacturing specification does not state a clinical aging outcome.

Absorption: A carrier position only for the fisetin–fenugreek galactomannan formulation in the 2022 pharmacokinetic study. The measured difference stays with that formulation.

Senolytic: Printed only when the brand supplies its own substantiation file. Public human trials on frailty and inflammation have not posted outcome results.

Manufacturing specifications: Botanical identity, assay, formula, pack, and the finished-unit records behind that label.

Manufacturing scope: Oral dietary supplements.

Separate review: Pregnancy, lactation, and products for minors.

These figures are for finished bottles. Drum quantities and drum dates are under Bulk Fisetin Powder.

Capsules: Planning starts at 3,000–5,000 capsules, depending on the formula, the pack, and the setup.

Tablets: Planning starts at 5,000–10,000 tablets, on the same conditions.

Sample: Typically 7–15 days after the finished-product specification is locked.

Production: Commonly 30–45 days after the formula, raw materials, packaging, and artwork are approved. A gummy, drink, liquid, or a new pack adds development and testing time.

The date that counts: The date on the order acknowledgement.

Reorder: The same specification, the same raw material, and the same tests.

Published capacity is on the manufacturing capacity page.